Author
David A. Bechtold
University of ManchesterORCID 0000-0001-8676-8704Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2016-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 45 mutual co-author links11 papers
Recent·Most cited
- ImmunologyMucosal ImmunologyPeer-reviewed
The club cell circadian clock regulates temporal patterns in leukocyte trafficking in chronic allergic airways disease
Jafar Cain, Amlan Chakraborty, Vishvangi Deugi…·Hannah Jane Durrington
This study shows the club cell circadian clock regulates time-of-day-dependent leukocyte trafficking and airway barrier integrity in chronic allergic airways disease.
DOI 10.1016/j.mucimm.2026.100384 - ImmunologyiSciencePeer-reviewed
Colonic inflammation modulates the intestinal circadian landscape
Thomas D. Butler, Polly J. Downton, Suzanna H. Dickson…·Julie Elizabeth Gibbs
This study examines how colonic inflammation affects the intestinal circadian clock and immune function, finding altered clock function and new oscillations in regulatory T cells.
6 citations - Cell BiologybioRxivPreprint
Ribosomal modification by BUD23 drives selective translational control over energy state and metabolic health
Noelia Martínez‐Sánchez, Anneke Brümmer, Nichola J. Barron…·David A. Bechtold
This study identifies BUD23 as a regulator of energy homeostasis by controlling translation of mitochondrial and lipogenic mRNAs, linking ribosomal modification to metabolic health.
- ImmunologyOpen BiologyPeer-reviewed
Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis
Polly J. Downton, Suzanna H. Dickson, David William Ray…·Julie Elizabeth Gibbs
This study shows that fibroblast-like synoviocytes' circadian clock influences daily inflammation rhythms in arthritis, with Bmal1 deletion reducing arthritis susceptibility but increasing MMP3 production.
12 citations - NeuroscienceProceedings of the National Academy of SciencesPeer-reviewed
Daytime light enhances the amplitude of circadian output in a diurnal mammal
Beatriz Baño‐Otálora, Franck P. Martial, Court Harding…·Robert James Lucas
This study shows that higher daytime light intensity increases circadian rhythm amplitude in the diurnal rodent Rhabdomys pumilio by affecting SCN electrophysiological activity.
95 citationstop 2% - Molecular BiologybioRxivPreprint
HNF4A is required to specify glucocorticoid action in the liver
Louise Hunter, Toryn M. Poolman, Donghwan Kim…·David William Ray
This study shows HNF4A is essential for liver-specific GR action, with HNF4A regulating GR binding sites and transcriptional response to glucocorticoids in the liver.
- GenomicsNature CommunicationsPeer-reviewed
Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups
Heming Wang, Jacqueline M. Lane, Samuel E. Jones…·Richa Saxena
This study identifies 42 genetic loci associated with excessive daytime sleepiness and links them to phenotypic subgroups and related traits.
238 citations - GeneticsNature CommunicationsPeer-reviewed
GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates
Hassan S. Dashti, Samuel E. Jones, Andrew R. Wood…·Richa Saxena
611 citationstop 1% - GenomicsNature GeneticsPeer-reviewed
Biological and clinical insights from genetics of insomnia symptoms
HUNT All In Sleep, Jacqueline M. Lane, Samuel E. Jones…·Richa Saxena
The paper identifies 57 genomic regions associated with insomnia symptoms, linking them to phototransduction, ubiquitination, and potential causal relationships with coronary heart disease and depression.
398 citationstop 1% - GeneticsNature GeneticsPeer-reviewed
Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits
Jacqueline M. Lane, Jingjing Liang, Irma Vlasac…·Richa Saxena
This study identifies new genetic loci associated with sleep disturbance traits and finds shared genetic links with neuropsychiatric and metabolic traits.
349 citationstop 1%