Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein
Darko Bosnakovski, Erik A. Toso, Elizabeth T. Ener, Micah D. Gearhart, Lulu Yin, Felipe F. Lüttmann, Alessandro Magli, Ke Shi, Johnny Kim, Hideki Aihara, Michael Kyba
The paper investigates the functional relationships among DUX family members, showing that DUXA acts as a competitive inhibitor of DUX4 and shares target gene overlap with it.
iScience · Sep 2, 2023Peer-reviewedMolecular Biology