Author

Justin S. Kolb

University of ArizonaORCID 0000-0002-4147-9287Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Carina Wallgren‐PetterssoniD· 1 shared Coen A. C. OttenheijmiD· 1 shared Edmar ZanoteliiD· 1 shared Esmat Karimi· 1 shared Henk Granzier· 1 shared Henk L. M. GranzieriD· 1 shared Jenni M. LaitilaiD· 1 shared Jochen GohlkeiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperPhysiology

Carina Wallgren‐PetterssonORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Myosin ATPase inhibition fails to rescue the metabolically dysregulated proteome of nebulin-deficient muscle

Jenni M. Laitila, Robert A. E. Seaborne, Natasha Ranu, Justin S. Kolb, Carina Wallgren‐Pettersson, Nanna Witting, John Vissing, Juan Jesus Vilchez, Edmar Zanoteli, Johanna Palmio, Sanna Huovinen, Henk Granzier, Julien Ochala

This study tests Mavacamten's ability to rescue metabolic dysregulation in nebulin-deficient muscle, finding it effective in vitro but ineffective in vivo for reversing the proteome changes.

The Journal of Physiology · Aug 31, 2024Peer-reviewedPhysiology

Characterization of NEB mutations in patients reveals novel nemaline myopathy disease mechanisms and omecamtiv mecarbil force effects

Esmat Karimi, Mila van der Borgh, Johan Lindqvist, Jochen Gohlke, Zaynab Hourani, Justin S. Kolb, Stacy A. Cossette, Michael William Lawlor, Coen A. C. Ottenheijm, Henk L. M. Granzier

This study characterizes NEB mutations in NEM2 patients, revealing mechanisms of nebulin dysfunction and the potential therapeutic benefit of Omecamtiv mecarbil.

bioRxiv · Dec 20, 2023 · PreprintGenetics