Xingchi Yan

The paper shows how changes in sister chromatid folding over time encode mechanisms of cohesion maintenance, revealing how transient cofactor interactions regulate long-lived cohesin protection.

This paper identifies Ab-trapping as a staining artifact in antibody-based techniques, showing it results from high epitope abundance, high Ab affinity, and low diffusion rates, and suggests mitigation strategies.

This paper develops a probabilistic algorithm to accurately identify and quantify intermolecular interactions using single-molecule localization microscopy.