Yunzhang Wang

This paper introduces a computational method to improve the reliability of epigenetic clocks by using principal component analysis, showing reduced technical noise and better performance in longitudinal studies.

This study identifies genetic correlations and shared loci between Parkinson disease and inflammatory bowel disease subtypes, highlighting immune-related pathways.

This study performs a genome-wide association study of frailty index to identify genetic signals and pathways, finding synapse function enrichment and associations with educational attainment.

In 159,701 siblings from 17 cohorts, population GWAS overstate direct effects on height, education, smoking, cognition, depressive symptoms and age at first birth; clinical traits mostly agree across models.

This study estimates mitochondrial DNA abundance in 295,150 UK Biobank participants and identifies genetic and lifestyle factors associated with it, finding links to immune aging, disease risk, and mortality.

This paper identifies DNA methylation sites associated with aggression through a meta-analysis of epigenome-wide studies across different age groups and tissues.

This study identifies 137 genome-wide significant loci associated with DNA methylation biomarkers of ageing using DNAm and SNP data from over 41,000 individuals.

This study examines DNA methylation outlier burden as a marker of biological age and finds it increases with age but is not strongly linked to health outcomes or survival.

This study examines the accumulation of epigenetic mutations with age using longitudinal blood samples and identifies factors influencing their occurrence.

This study identifies age-related DNA methylation changes in old Swedish twins over 20 years, showing stability across cohorts and genetic influences independent of age.

This study investigates the association between CpG methylation and educational attainment, finding limited significant associations that may be influenced by confounding factors.