Amy Conaway

Pseudomonas aeruginosa LasR-deficient mutants have increased methylglyoxal and hydrogen peroxide sensitivity due to low intracellular glutathione

This study shows that Pseudomonas aeruginosa LasR mutants are more sensitive to methylglyoxal and hydrogen peroxide due to reduced intracellular glutathione.

Loss of LasR function leads to decreased repression of Pseudomonas aeruginosa PhoB activity at physiological phosphate concentrations

This paper shows that loss of LasR function in Pseudomonas aeruginosa increases PhoB activity at physiological phosphate concentrations, contributing to increased virulence.