Pseudomonas aeruginosa lasR Mutants Resist Phagocytosis and Alter Inflammatory Cytokine Production by Cystic Fibrosis Macrophages
Daniel S Aridgides, Diane Mellinger, Lorraine L. Gwilt…·Alix Ashare
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Dartmouth CollegeORCID 0000-0001-6939-1351Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
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Daniel S Aridgides, Diane Mellinger, Lorraine L. Gwilt…·Alix Ashare
Emma L. Kane, B. Chan, Dallas L. Mould…·P. Turner
This study evaluates the synergy between phage OMKO1 and five antibiotics against Pseudomonas aeruginosa, showing reduced MIC and resistant regrowth in four of five combinations.
Amy Conaway, Igor Todorovic, Dallas L. Mould, Deborah A. Hogan
This paper shows that loss of LasR function in Pseudomonas aeruginosa increases PhoB activity at physiological phosphate concentrations, contributing to increased virulence.
Stacie E. Stuut, Dallas L. Mould, Fabrice Jean-Pierre, Deborah A. Hogan
This study shows Pseudomonas aeruginosa consumes nitrate in oxic conditions, requiring Dnr and Dnr-regulated NorCB for detoxification, despite no growth advantage from nitrate.
Alexandra J. Lee, Dallas L. Mould, Jake Crawford…·Casey S. Greene
This paper introduces SOPHIE, a method using generative neural networks to distinguish common from specific transcriptional responses across datasets.