Kevin Struhl

TRiC/CCT Chaperonin Governs RNA Polymerase II Activity in the Nucleus to Support RNA Homeostasis

This study shows TRiC/CCT regulates RNA polymerase II activity in the nucleus, affecting RNA homeostasis by modulating nascent RNA production.

Nucleotide level linkage of transcriptional elongation and polyadenylation

The paper shows that Pol II elongation speed affects poly(A) site clustering and that poly(A) site clusters are linked to local elongation rates and DNA sequence elements.

High level and molecular nature of transcriptional noise in yeast cells

This study measures transcriptional noise in yeast by analyzing random-sequence DNA and finds higher cell-to-cell variability in RNAs from random-sequence DNA compared to yeast genomic DNA.

MafB, WDR77, and ss-catenin interact with each other and have similar genome association profiles

The paper identifies interactions between MafB, WDR77, and β-catenin and shows they share similar genomic binding profiles near paused RNA polymerase at promoter-proximal regions.

Different SP1 binding dynamics at individual genomic loci in human cells

The paper shows SP1 has different binding dynamics at genomic loci in human cells, with slow turnover sites enriched in enhancers and fast turnover sites having more SP1 motifs.

YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation

This study identifies YAP and TAZ as transcriptional co-activators of AP-1 and STAT3 in breast cancer, showing their role in gene regulation and poor patient survival.

Promoter-specific dynamics of TATA-binding protein association with the human genome

The paper measures TBP binding dynamics across the human genome using ChIP-seq and finds that TBP turnover varies among promoters and correlates with transcriptional activity and regulatory elements.

Regulatory network controlling tumor-promoting inflammation in human cancers

The paper identifies a transcriptional regulatory network involving STAT3, NF-κB, and AP-1 that drives tumor-promoting inflammation in cancers, linking inflammation to immune infiltration and genome instability.