Yuko Hasegawa

This study shows IL-22 promotes mucus-secreting cells in the small intestine, protecting mice from cholera by reducing V. cholerae colonization.

The paper introduces CIERA-seq to study transcription regulatory element interactions and finds pdTREs and edTREs have distinct functional and chromatin features.

The paper shows SP1 has different binding dynamics at genomic loci in human cells, with slow turnover sites enriched in enhancers and fast turnover sites having more SP1 motifs.

The paper measures TBP binding dynamics across the human genome using ChIP-seq and finds that TBP turnover varies among promoters and correlates with transcriptional activity and regulatory elements.