Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights from Comprehensive Multicenter Preclinical Studies
Sarah-Eve S Lemay, Mónica S. Montesinos, Yann Grobs, Tetsuro Yokokawa, Tsukasa Shimauchi, Manon Mougin, Charlotte Romanet, Mélanie Sauvaget, Sandra Breuils‐Bonnet, Alice Bourgeois, Charlie Théberge, Andréanne Pelletier, Reem El Kabbout, Sandra Martineau, Keiko Yamamoto, , Sébastien Bonnet
The study identifies integrin α5β1 as a key driver of pulmonary vascular remodeling in PAH and shows its inhibition improves hemodynamics and RV function in preclinical models.
Circulation · Jan 20, 2025Peer-reviewedPathology