Author

Reem El Kabbout

Institut universitaire de cardiologie et de pneumologie de Québec

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

François PotusiD· 3 shared Manon MouginiD· 3 shared Olivier BoucheratiD· 3 shared Sébastien BonnetiD· 3 shared Steeve ProvencheriD· 3 shared Yann GrobsiD· 3 shared Alice Bourgeois· 2 shared Charlie Théberge· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

François PotusORCID

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Author profile →

3 papers

Recent·Most cited

Levosimendan Ameliorates Adverse Pulmonary Vascular Remodeling in Group-2 Pulmonary Hypertension.

Antonella Abi-Sleimen, Ruaa Al‐Qazazi, Yann Grobs, Yahe Xu, Tsukasa Shimauchi, Ashley Y Martin, Danchen Wu, Reem El Kabbout, Manon Mougin, Charlie Théberge, Steeve Provencher, Olivier Boucherat, Sébastien Bonnet, Stephen L. Archer, François Potus

This study develops preclinical models of Group-2 pulmonary hypertension and shows that levosimendan improves cardiac function and reduces pulmonary vascular inflammation and remodeling.

bioRxiv · Oct 23, 2025 · PreprintMolecular Biology

Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights from Comprehensive Multicenter Preclinical Studies

Sarah-Eve S Lemay, Mónica S. Montesinos, Yann Grobs, Tetsuro Yokokawa, Tsukasa Shimauchi, Manon Mougin, Charlotte Romanet, Mélanie Sauvaget, Sandra Breuils‐Bonnet, Alice Bourgeois, Charlie Théberge, Andréanne Pelletier, Reem El Kabbout, Sandra Martineau, Keiko Yamamoto, , Sébastien Bonnet

The study identifies integrin α5β1 as a key driver of pulmonary vascular remodeling in PAH and shows its inhibition improves hemodynamics and RV function in preclinical models.

Circulation · Jan 20, 2025Peer-reviewedPathology

ATP Citrate Lyase Drives Vascular Remodeling Diseases Development Through Metabolic-Epigenetic Reprograming.

Yann Grobs, Charlotte Romanet, Sarah-Eve Lemay, Alice Bourgeois, Pierre Voisine, Charlie Theberge, Melanie Sauvaget, Sandra Breuils-Bonnet, Sandra Martineau, Reem El Kabbout, Manon Mougin, Elizabeth Dumais, Jean Perron, Nicolas Flamand, François Potus, , Sebastien Bonnet

This study identifies ATP-citrate lyase as a driver of vascular remodeling in pulmonary hypertension and coronary artery disease, showing its inhibition can reverse pathological changes.

bioRxiv · Feb 2, 2024 · PreprintPhysiology