Author

Tsukasa Shimauchi

St Mary's HospitalORCID 0000-0002-9834-4770Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Charlie Théberge· 2 shared François PotusiD· 2 shared Manon MouginiD· 2 shared Olivier BoucheratiD· 2 shared Reem El Kabbout· 2 shared Sébastien BonnetiD· 2 shared Steeve ProvencheriD· 2 shared Yann GrobsiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Charlie Théberge

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2 papers

Recent·Most cited

Levosimendan Ameliorates Adverse Pulmonary Vascular Remodeling in Group-2 Pulmonary Hypertension.

Antonella Abi-Sleimen, Ruaa Al‐Qazazi, Yann Grobs, Yahe Xu, Tsukasa Shimauchi, Ashley Y Martin, Danchen Wu, Reem El Kabbout, Manon Mougin, Charlie Théberge, Steeve Provencher, Olivier Boucherat, Sébastien Bonnet, Stephen L. Archer, François Potus

This study develops preclinical models of Group-2 pulmonary hypertension and shows that levosimendan improves cardiac function and reduces pulmonary vascular inflammation and remodeling.

bioRxiv · Oct 23, 2025 · PreprintMolecular Biology

Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights from Comprehensive Multicenter Preclinical Studies

Sarah-Eve S Lemay, Mónica S. Montesinos, Yann Grobs, Tetsuro Yokokawa, Tsukasa Shimauchi, Manon Mougin, Charlotte Romanet, Mélanie Sauvaget, Sandra Breuils‐Bonnet, Alice Bourgeois, Charlie Théberge, Andréanne Pelletier, Reem El Kabbout, Sandra Martineau, Keiko Yamamoto, , Sébastien Bonnet

The study identifies integrin α5β1 as a key driver of pulmonary vascular remodeling in PAH and shows its inhibition improves hemodynamics and RV function in preclinical models.

Circulation · Jan 20, 2025Peer-reviewedPathology