ImmunologyBloodPeer-reviewed
Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues ameliorating GVHD post-HSCT
Duneia McManus, Sabrina N. Copsel, Brent J. Pfeiffer…·Robert B. Levy
This paper shows that pretransplant targeting of TNFRSF25 and CD25 with a TL1A-Ig fusion protein and low-dose IL-2 expands recipient Tregs, reducing GVHD after HSCT while preserving GVL.
4 citations