Gintautas Tamulaitis

This study identifies Csx15 as a ring nuclease that degrades cyclic nucleotides from both CRISPR-Cas and CBASS systems, revealing its role in regulating signaling pathways.

The paper characterizes the CRISPR SAVED-Lon system, showing that filament formation activates protease and ring nuclease activities, leading to growth arrest in E. coli.

This study demonstrates that CRISPR endoribonucleases can efficiently knock down mRNA transcripts in zebrafish, with varying effectiveness across different EGFP-expressing lines.