Florian Jeanneret

Human decellularized extracellular matrix from adipose tissue is a permissive microenvironment for pancreatic organoids generation

This study develops a decellularized adipose tissue-derived hydrogel (atdECM) that supports pancreatic organoid growth with improved transcriptional profiles compared to Matrigel.

Efficient fine-tuning of endothelial gene expression by Y to Phe mutation in the VE-cadherin gene

The paper investigates the effect of a Y685F mutation in VE-cadherin on endothelial gene expression, identifying 884 differentially expressed genes and altered signaling pathways in vivo.

DNA methylation subtypes inferred from transcriptomes guide sunitinib and immunotherapy selection in renal cancer

The paper identifies DNA methylation subtypes from transcriptomes to guide sunitinib and immunotherapy selection in renal cancer, finding hyper-methylated tumors respond better to atezolizumab plus bevacizumab.

Microenvironment of metastasis reveals key predictors of PD-1 blockade response in renal cell carcinoma

The paper identifies key predictors of PD-1 blockade response in renal cell carcinoma by analyzing the tumor microenvironment of metastatic sites and developing a predictive TID score.

Towards an integrative multi-omics workflow

The paper proposes an integrative multi-omics workflow for breast cancer data to improve pathway enrichment analysis by combining sPLS-DA features with Stouffers Z scores method.