Koichi Takahashi

Replication-dependent histone (Repli-Histo) labeling dissects the physical properties of euchromatin/heterochromatin in living human cells.

The paper develops Repli-Histo labeling to study nucleosome motion in euchromatin and heterochromatin, finding that euchromatic regions exhibit greater motion and influence replication timing.

Robotic Search for Optimal Cell Culture in Regenerative Medicine

A robotic AI system using Bayesian optimization accelerates iPSC-RPE cell differentiation, achieving 88% better pigmented scores than pre-optimized methods.

pSpatiocyte: a high-performance simulator for intracellular reaction-diffusion systems

pSpatiocyte is a high-performance simulator for intracellular reaction-diffusion systems that achieves significant speedup and efficiency in large-scale simulations.

Multi-algorithm particle simulations with Spatiocyte

Spatiocyte simulates biochemical reaction and diffusion processes using multi-algorithm and multi-timescale frameworks to model spatially regulated systems.