Koichi Higashi

An iPSC-based experimental framework for investigating phenotypic variation associated with Jomon ancestry in the present-day Japanese population

The paper develops a hiPSC-based framework to study ancestry-related phenotypic variation in the Japanese population, finding no hepatic triglyceride differences despite genetic associations.

Cohesin prevents local mixing of condensed euchromatic domains in living human cells

This study shows cohesin maintains condensed euchromatic domains in human cells by preventing local mixing, which is crucial for transcriptional insulation.

Benchmarking long-context genome language models on biosynthetic gene clusters

This study benchmarks long-context genome language models on biosynthetic gene clusters, showing layer selection impacts performance and revealing how models encode biological information.

Concentration-dependent formation of intersegment interactions in viral droplets of influenza A virus infected cells

This study identifies intersegment interactions in influenza A virus infected cells using LIGR-seq, showing they form in viral inclusions and are influenced by vRNP concentration and Rab11.

Replication-dependent histone (Repli-Histo) labeling dissects the physical properties of euchromatin/heterochromatin in living human cells.

The paper develops Repli-Histo labeling to study nucleosome motion in euchromatin and heterochromatin, finding that euchromatic regions exhibit greater motion and influence replication timing.

Automated Harmonization and Large-Scale Integration of Heterogeneous Biomedical Sample Metadata Using Large Language Models

This paper introduces a framework using large language models to automate metadata harmonization and integration across biomedical studies, achieving higher recovery rates than traditional methods.

Metagenomic thermometer

The paper develops a Metagenomic Thermometer to predict environmental temperature from metagenomic sequences, achieving high accuracy in hot spring samples and estimating human body temperature.