Genshiro A. Sunagawa

A thermoregulatory design principle for transitions into hypometabolism

The paper identifies dynamical signatures and a mathematical principle underlying the transition from normothermia to hypothermia in mammals.

A single-nucleus and spatial transcriptomic atlas of the Syrian hamster preoptic area across hibernation states

This study creates a transcriptomic atlas of the Syrian hamster preoptic area using snRNA-seq and spatial transcriptomics, comparing seasonal and hibernation states.

Repetitive induction of a hibernation-like brain state slows amyloid pathology

The paper shows that inducing a hibernation-like brain state in AD mice slows amyloid plaque accumulation and reduces neuroinflammation without targeting specific pathways.

EvoPRAISE: computationally guided directed evolution for rational AAV capsid engineering

This paper develops EvoPRAISE, a framework combining structure-based affinity prediction and directed evolution to design AAV capsids targeting the BBB in non-model species and humans.

Contactless metabolism estimation of small animals using high-frequency millimeter-wave radar

This study develops a system to estimate oxygen consumption in small animals using millimeter-wave radar and machine learning, enabling contactless and low-cost measurements.

Robotic Search for Optimal Cell Culture in Regenerative Medicine

A robotic AI system using Bayesian optimization accelerates iPSC-RPE cell differentiation, achieving 88% better pigmented scores than pre-optimized methods.