Author

Rachel R Litke

Icahn School of Medicine at Mount SinaiORCID 0000-0002-4236-1360Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Aaron E. SilveriD· 1 shared Bik Tzu HuangiD· 1 shared Charles V. MobbsiD· 1 shared Christopher Paul KellneriD· 1 shared H. Ümit KanıskaniD· 1 shared Irene RamosiD· 1 shared James M. VicariiD· 1 shared Jian Jun JiniD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Aaron E. SilverORCID

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1 paper

Recent·Most cited

Novel small molecules inhibit proteotoxicity and inflammation: Mechanistic and therapeutic implications for Alzheimer's Disease, healthspan and lifespan- Aging as a consequence of glycolysis

Rachel R Litke, James M. Vicari, Bik Tzu Huang, Lila R. Shapiro, Kun-Hyung Roh, Aaron E. Silver, Pooja Talreja, Nicolle Palacios, Yonejung Yoon, Christopher Paul Kellner, H. Ümit Kanıskan, Sindhu Vangeti, Jian Jun Jin, Irene Ramos, Charles V. Mobbs

The paper identifies small molecules that inhibit proteotoxicity and inflammation in Alzheimer's Disease models, revealing mechanisms linking glycolysis to neuroinflammation and suggesting new therapeutic targets.

bioRxiv · Jun 12, 2023 · PreprintNeuroscience