Neonatal microbiota colonization drives maturation of primary and secondary goblet cell mediated protection in the pre-weaning colon
Åsa Johansson, Mahadevan Venkita Subramani, Bahtiyar Yılmaz, Elisabeth E. L. Nyström, Elena Layunta, Liisa Arike, Felix Sommer, Philip C Rosenstiel, Lars Vereecke, Louise Mannerås-Holm, Andy Wullaert, Thaher Pelaseyed, M. E. V. Johansson, George M. H. Birchenough
This study shows that neonatal microbiota colonization sequentially programs primary and secondary goblet cell functions in the colon, with MyD88 and Duox2 playing key roles in mucus barrier and sentinel cell development.
The Journal of Experimental Medicine · Apr 4, 2025Peer-reviewedImmunology