Cryo-EM structure of CLCA1 identifies CLCA1 as a founding member of a novel metzincin family.
Elisabeth E. L. Nyström, Sjoerd van der Post, Doireann Bradley Barrett, Grete Raba, Thaher Pelaseyed, Mihai Oltean, Ana Sofia Luis, Sergio Trillo‐Muyo
The paper determines the Cryo-EM structure of CLCA1, revealing its unique domain organization and regulatory mechanisms, and identifies it as a founding member of a new metzincin family.
bioRxiv · Oct 18, 2025 · PreprintMolecular Biology