Felix Sommer

Systematic screening of tryptophan metabolism identifies site- and microbial-specific signatures of tryptophan utilization in experimental colitis

This study identifies microbial-specific Trp metabolism signatures in colitis by analyzing metabolites across multiple compartments in mice treated with DSS and antibiotics.

Long-Term Intestinal Epithelial Remodeling Induced by Acute Protein-Energy Malnutrition

This study investigates long-term intestinal epithelial changes after acute protein-energy malnutrition using multi-omics approaches and identifies microbial lipid metabolites and epigenetic factors as key drivers of persistent Paneth cell dysfunction.

Neonatal microbiota colonization drives maturation of primary and secondary goblet cell mediated protection in the pre-weaning colon

This study shows that neonatal microbiota colonization sequentially programs primary and secondary goblet cell functions in the colon, with MyD88 and Duox2 playing key roles in mucus barrier and sentinel cell development.

Metabolic modeling reveals the aging-associated decline of host-microbiome metabolic interactions in mice

This study uses multi-omics and metabolic modeling in mice to show that aging reduces host-microbiome metabolic interactions, affecting key host pathways involved in intestinal barrier function and homeostasis.

Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis in mice

This study shows that deleting HKDC1 in intestinal epithelial cells reduces tumor growth and protects against colorectal cancer in mice by impairing mitochondrial function and cell proliferation.

Hexokinase 2 expression in apical enterocytes correlates with inflammation severity in patients with inflammatory bowel disease

The paper examines the relationship between HK2 expression and inflammation severity in IBD patients using bulk transcriptome data and confirms findings at the cellular and protein levels.