Liisa Arike

The paper shows ETEC protease EatA degrades human MUC2 mucin specifically, enabling bacterial infection by disrupting the intestinal mucus layer.

The paper identifies proteomic differences in bronchoalveolar lavage fluid at 12 months post-lung transplant that correlate with stable graft function versus early chronic lung allograft dysfunction.

This study shows that neonatal microbiota colonization sequentially programs primary and secondary goblet cell functions in the colon, with MyD88 and Duox2 playing key roles in mucus barrier and sentinel cell development.

This study identifies BPP43_05035 as a Brachyspira pilosicoli adhesin that disrupts epithelial tight junctions, increasing barrier permeability during infection.

The paper identifies MUC17 as a critical component of the small intestinal glycocalyx that is disrupted in Crohn's disease, leading to bacterial contact and epithelial defects.

The paper compares mucus composition and structure in COPD, CF, and colonic mucus, finding similarities in proteomes and a protective attached mucus layer in the lungs.