Thaher Pelaseyed

This study identifies that a minimal glycocalyx on host cell membranes optimally facilitates Salmonella Typhimurium targeting, with glycoproteins and cholesterol playing key roles.

This study shows that maturation of human intestinal epithelial cells reduces susceptibility to Salmonella invasion by altering actin regulation, mucin expression, and glycocalyx composition.

The paper identifies proteomic differences in bronchoalveolar lavage fluid at 12 months post-lung transplant that correlate with stable graft function versus early chronic lung allograft dysfunction.

The paper determines the Cryo-EM structure of CLCA1, revealing its unique domain organization and regulatory mechanisms, and identifies it as a founding member of a new metzincin family.

This study investigates the postnatal maturation of the small intestinal epithelium, identifying developmental regulators as key drivers over microbiota effects.

This study shows that neonatal microbiota colonization sequentially programs primary and secondary goblet cell functions in the colon, with MyD88 and Duox2 playing key roles in mucus barrier and sentinel cell development.

This study identifies BPP43_05035 as a Brachyspira pilosicoli adhesin that disrupts epithelial tight junctions, increasing barrier permeability during infection.

The paper identifies MUC17 as a critical component of the small intestinal glycocalyx that is disrupted in Crohn's disease, leading to bacterial contact and epithelial defects.

The paper identifies a previously unmapped MUC3B gene within a conserved membrane mucin gene cluster on human chromosome 7 and shows its exclusive expression in intestinal epithelial cells.