The preferential injury of outer renal medulla after ischemia-reperfusion relies on high oxidative metabolism
Grégoire Arnoux, Justine Serre, Thomas Verissimo, Matthieu Tihy, Sandrine Placier, Charles Verney, Frédéric Sangla, Deborah Paolucci, Marylise Fernandez, Sophie de Seigneux, Sebastian Douglas Sgardello, Maarten Naesens, Juliette Hadchouel, Eric Féraille, Stellor Nlandu Khodo, , David Legouis
This study identifies the outer stripe of the outer medulla as the most metabolically active and injured region in the kidney during ischemia-reperfusion injury, showing propofol exacerbates this damage through mitochondrial and fatty acid oxidation impairment.
bioRxiv · Sep 12, 2024 · PreprintPhysiology