Maarten Naesens

Non-HLA antibodies worsen the histological phenotype and prognosis of antibody mediated rejection in kidney allografts

This study shows non-HLA antibodies are linked to worse histology and graft outcomes in kidney transplant patients with antibody-mediated rejection, especially when combined with HLA-DSAs.

Tissular glucocorticoid reactivating enzyme 11beta-HSD1 drives pathogenic myofibroblast differentiation in chronic kidney disease

This study identifies 11beta-HSD1 as a driver of myofibroblast differentiation in CKD, showing its inhibition reduces fibrosis and improves renal function.

The preferential injury of outer renal medulla after ischemia-reperfusion relies on high oxidative metabolism

This study identifies the outer stripe of the outer medulla as the most metabolically active and injured region in the kidney during ischemia-reperfusion injury, showing propofol exacerbates this damage through mitochondrial and fatty acid oxidation impairment.

Inflammasome Profiling in Human Natural Killer Cells under Pro-inflammatory Stimuli and Solid Organ Transplantation

This study shows human NK cells can activate inflammasomes in vitro and in transplant patients, with distinct responses in CD56 subsets and sustained activation in renal dysfunction and transplant rejection.

Deep-learning Based Pathological Assessment of Frozen Procurement Kidney Biopsies Predicts Graft Loss and Guides Organ Utilization: A Large-scale Retrospective Study

This paper develops a deep-learning model to assess kidney biopsy images, predicting graft loss and guiding organ utilization by improving upon traditional scoring methods.