Stefan Semrau

The paper identifies genetic factors influencing iPSC growth rates, finding rare variants in WDR54 and a polygenic background explaining most variance.

The paper develops a live cell imaging assay using patient-derived ovarian cancer organoids to study natural killer cell-mediated apoptosis and identifies resistant organoid populations.

This study uses gastruloids to investigate the mechanisms of elongation during gastrulation, showing that convergent extension and differential adhesion together explain the observed shape changes.

The paper identifies ETV2 dynamics in hiPSC-derived cardiac lineages using single-cell RNA-seq and a fluorescent reporter, revealing distinct subpopulations for endothelial and cardiomyocyte specification.

The paper introduces SIGMA, a clusterability measure to identify meaningful subpopulations in single-cell transcriptomics data, leading to the discovery of previously overlooked phenotypes.

The paper shows that adding XEN cells to mouse gastruloids induces neuroepithelial tissue formation through reciprocal differentiation and WNT signaling inhibition.

The paper measures mRNA and protein levels during ESC differentiation, revealing widespread discordance and using a kinetic model to identify post-transcriptional regulation.

This study uses single-cell transcriptomics to analyze lineage commitment in differentiating mouse embryonic stem cells, identifying key transcriptional changes and a phase of susceptibility to lineage signals.

This study quantifies core ribosomal protein stoichiometry in mouse embryonic stem cells and yeast, showing variability influenced by growth conditions and ribosome-mRNA binding.

The paper develops a single-cell RNA-Seq protocol to analyze adipogenic differentiation and finds an inverse relationship between inflammatory gene expression and lipid accumulation in human cells.