Maria Mircea

From Brown to White: Brown Adipose Tissue Endothelial Cells whiten in Culture Conditions

This paper isolates and cultures endothelial cells from brown and white adipose tissue, showing that brown adipose tissue endothelial cells lose their identity in culture and adopt features of white adipose and lymphatic endothelial cells.

A combination of convergent extension and differential adhesion explains the shapes of elongating gastruloids

This study uses gastruloids to investigate the mechanisms of elongation during gastrulation, showing that convergent extension and differential adhesion together explain the observed shape changes.

ETV2 upregulation marks the specification of early cardiomyocytes and endothelial cells during co-differentiation

The paper identifies ETV2 dynamics in hiPSC-derived cardiac lineages using single-cell RNA-seq and a fluorescent reporter, revealing distinct subpopulations for endothelial and cardiomyocyte specification.

Tissue microenvironment dictates the state of human induced pluripotent stem cell-derived endothelial cells of distinct developmental origin in 3D cardiac microtissues

A clusterability measure for single-cell transcriptomics reveals phenotypic subpopulations

The paper introduces SIGMA, a clusterability measure to identify meaningful subpopulations in single-cell transcriptomics data, leading to the discovery of previously overlooked phenotypes.

Extraembryonic endoderm cells induce neuroepithelial tissue in gastruloids

The paper shows that adding XEN cells to mouse gastruloids induces neuroepithelial tissue formation through reciprocal differentiation and WNT signaling inhibition.

Single cell RNA-seq denoising using a deep count autoencoder

This paper introduces a deep count autoencoder (DCA) for denoising scRNA-seq data, showing it improves analysis quality and speed compared to existing methods.