Cancer BiologybioRxivPreprint
Local, but not circulating, complement C3 governs immune checkpoint blockade efficacy
Yuki Miyai, Yukihiro Shiraki, Daisuke Sugiyama…·Atsushi Enomoto
This study shows that locally produced C3 in cancer-associated fibroblasts, not circulating C3, determines immune checkpoint blockade efficacy by modulating myeloid cell infiltration.