Author

Tulasigeri M. Totiger

University of MiamiORCID 0000-0002-4262-4458Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Adnan Kasim MookhtiariD· 1 shared Anna Lesley Kingham· 1 shared Daniel BilbaoiD· 1 shared Efe KaracaiD· 1 shared Felipe BeckedorffiD· 1 shared Glòria Mas MartíniD· 1 shared Guilherme Miura LavezzoiD· 1 shared Helena Gomes Dos SantosiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Adnan Kasim MookhtiarORCID

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1 paper

Recent·Most cited

Co-targeting menin and LSD1 dismantles oncogenic programs and restores differentiation in MLL-rearranged AML

Mina Masoumeh Tayari, Helena Gomes Dos Santos, Felipe Beckedorff, Tulasigeri M. Totiger, Adnan Kasim Mookhtiar, Anna Lesley Kingham, Guilherme Miura Lavezzo, Glòria Mas Martín, Hsuan-Ting Huang, Efe Karaca, Daniel Bilbao, Justin Taylor, Ramin Shiekhattar, Justin M. Watts

This study identifies LSD1 as a cofactor of the menin-MLL-LEDGF complex and shows that combining menin and LSD1 inhibition effectively treats MLL-rearranged AML by dismantling oncogenic programs and promoting differentiation.

bioRxiv · Oct 13, 2025 · PreprintCancer Biology