Helena Gomes Dos Santos

Integrator governs NF-κB dwell time on chromatin to drive inflammatory transcription

This study identifies the Integrator complex as a key factor stabilizing NF-κB chromatin residence, essential for inflammatory gene activation in mouse and human cells.

Co-targeting menin and LSD1 dismantles oncogenic programs and restores differentiation in MLL-rearranged AML

This study identifies LSD1 as a cofactor of the menin-MLL-LEDGF complex and shows that combining menin and LSD1 inhibition effectively treats MLL-rearranged AML by dismantling oncogenic programs and promoting differentiation.

Balancing Activation and Repression: CoREST-p300 Antagonism Controls Retinoic Acid-Driven Differentiation in AML

The paper shows that Corin, a dual LSD1/CoREST inhibitor, synergizes with ATRA to induce differentiation and apoptosis in AML by disrupting CoREST-RAR/RXR complexes and recruiting p300.

Enhancing Transcriptome Mapping with Rapid PRO-seq Profiling of Nascent RNA

This paper introduces rPRO-seq, a rapid PRO-seq method for nascent RNA profiling, and applies it to study Integrator's role in mouse hematopoietic stem cell homeostasis.

The Integrator complex regulates microRNA abundance through RISC loading

This study shows that the Integrator complex is essential for miRNA abundance by facilitating their loading into RISC.