Author
University of MiamiORCID 0000-0003-3521-8782Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Mina Masoumeh Tayari, Helena Gomes Dos Santos, Felipe Beckedorff…·Justin M. Watts
This study identifies LSD1 as a cofactor of the menin-MLL-LEDGF complex and shows that combining menin and LSD1 inhibition effectively treats MLL-rearranged AML by dismantling oncogenic programs and promoting differentiation.
Mina Masoumeh Tayari, Helena Gomes Dos Santos, Sadat Dokaneheifard…·Ramin Shiekhattar
The paper shows that Corin, a dual LSD1/CoREST inhibitor, synergizes with ATRA to induce differentiation and apoptosis in AML by disrupting CoREST-RAR/RXR complexes and recruiting p300.
Nina Kirstein, Sadat Dokaneheifard, Pradeep Reddy Cingaram…·Ramin Shiekhattar
This study shows that the Integrator complex is essential for miRNA abundance by facilitating their loading into RISC.