Cell BiologybioRxivPreprint
Branched-chain amino acid metabolism is a crucial modulator of cellular senescence
Yuma Aramaki, Kazuki Irie, Hideru Obinata…·Akimitsu Konishi
This study shows that changes in branched-chain amino acid (BCAA) metabolism, specifically reduced BCAT2 activity, drive cellular senescence in cultured cells and mice, and link aging to altered BCAA metabolism in humans.