Satoko Arakawa

Partitioning of nuclear material into apoptotic fragments through establishment of asymmetric cell death morphology

This study identifies a new apoptotic morphology, AsyCDM, where apoptotic cells asymmetrically partition nuclear material into apoptotic bodies via ROCK1-dependent actomyosin contraction.

Biogenesis and antigen presentation properties of dendritic cell-derived apoptotic bodies

This study shows that apoptotic dendritic cells release large extracellular vesicles called apoptotic bodies that can directly present antigens and modulate immune responses.

The lack of macrophage fragment adhesion is a benchmark of dormant hematopoietic stem cells throughout the lifespan

This study identifies macrophage fragment adhesion as a marker to distinguish dormant hematopoietic stem cells from proliferative ones across the lifespan.

Branched-chain amino acid metabolism is a crucial modulator of cellular senescence

This study shows that changes in branched-chain amino acid (BCAA) metabolism, specifically reduced BCAT2 activity, drive cellular senescence in cultured cells and mice, and link aging to altered BCAA metabolism in humans.