Branched-chain amino acid metabolism is a crucial modulator of cellular senescence
Yuma Aramaki, Kazuki Irie, Hideru Obinata, Shinya Honda, Takuro Horii, Satoko Arakawa, Aiko Tsuchida, Junki Hoshino, Ryosuke Kobayashi, Takashi Izumi, Izuho Hatada, Shigeomi Shimizu, Yoji Andrew Minamishima, Akimitsu Konishi
This study shows that changes in branched-chain amino acid (BCAA) metabolism, specifically reduced BCAT2 activity, drive cellular senescence in cultured cells and mice, and link aging to altered BCAA metabolism in humans.
bioRxiv · Sep 10, 2024 · PreprintCell Biology