Akimitsu Konishi

This study evaluates the effects of five HIF-PH inhibitors on Vegfa expression in the retina and other tissues of mice, finding differential regulation across tissues and suggesting retinal VEGF upregulation as a safety concern.

This study shows that STARD7 loss disrupts mitochondrial phospholipid homeostasis, leading to impaired function and myopathy in skeletal muscle.

This study shows that changes in branched-chain amino acid (BCAA) metabolism, specifically reduced BCAT2 activity, drive cellular senescence in cultured cells and mice, and link aging to altered BCAA metabolism in humans.