Drug Reinforcement Impairs Cognitive Flexibility by Inhibiting Striatal Cholinergic Neurons
Himanshu Gangal, Xueyi Xie, Zhenbo Huang, Yifeng Cheng, Xuehua Wang, Jiayi Lu, Xiaowen Zhuang, Amanda Essoh, Yufei Huang, Ruifeng Chen, Laura N. Smith, Rachel J. Smith, Jun Wang
This paper shows that drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic interneurons through enhanced inhibitory transmission from direct-pathway medium spiny neurons.
Nature Communications · Jun 30, 2023Peer-reviewedNeuroscience