Laura N. Smith

This paper shows that drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic interneurons through enhanced inhibitory transmission from direct-pathway medium spiny neurons.

This study shows chronic alcohol consumption impairs cognitive flexibility by reducing thalamic excitation of cholinergic neurons in the dorsomedial striatum.

This study shows that FMRP helps adjust cocaine self-administration behavior to maintain reinforcement levels, as seen in Fmr1 KO mice with reduced Arc expression.