Author

Amanda Essoh

Texas A&M Health Science CenterORCID 0000-0002-7899-5920Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:electronic health records· 2 Research Focus:gene regulatory network inference· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Jun WangiD· 3 shared Xueyi XieiD· 3 shared Himanshu GangaliD· 2 shared Zhenbo HuangiD· 2 shared Jiayi LuiD· 1 shared Laura N. SmithiD· 1 shared Lierni UgartemendiaiD· 1 shared Maria Elena SecciiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

Jun WangORCID

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3 papers

Recent·Most cited

Extended Amygdala CRF Projections to Striatal Striosomes Potentiate Dopamine Suppression During Fentanyl Withdrawal

Xueyi Xie, Amanda Essoh, Ruifeng Chen, Xuehua Wang, Jun Wang

This paper identifies a CRF pathway in the extended amygdala that enhances striosomal suppression of dopamine during fentanyl withdrawal.

bioRxiv · Jun 26, 2026 · PreprintNeuroscience

Alcohol Attenuates CRF-Induced Excitatory Effects from the Extended Amygdala to Dorsostriatal Cholinergic Interneurons

Amanda Essoh, Xueyi Xie, Himanshu Gangal, Zhenbo Huang, Ruifeng Chen, Ziyi Li, Xuehua Wang, Valerie Vierkant, Miguel Garza, Lierni Ugartemendia, Maria Elena Secci, Nicholas W. Gilpin, Nicholas J. Justice, Robert O. Messing, Jun Wang

This paper identifies a CRF-CIN pathway linking the extended amygdala to the dorsal striatum and shows alcohol disrupts CRF-induced cholinergic activity.

eLife · Mar 23, 2026Peer-reviewedNeuroscience

Drug Reinforcement Impairs Cognitive Flexibility by Inhibiting Striatal Cholinergic Neurons

Himanshu Gangal, Xueyi Xie, Zhenbo Huang, Yifeng Cheng, Xuehua Wang, Jiayi Lu, Xiaowen Zhuang, Amanda Essoh, Yufei Huang, Ruifeng Chen, Laura N. Smith, Rachel J. Smith, Jun Wang

This paper shows that drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic interneurons through enhanced inhibitory transmission from direct-pathway medium spiny neurons.

Nature Communications · Jun 30, 2023Peer-reviewedNeuroscience