Prakash Kara

Hippocampal CA2 neurons disproportionately express AAV-delivered genetic cargo

This study investigates AAV tropism in hippocampal CA2 neurons, finding high expression of AAV-delivered genetic material due to abundant AAVR and glycan receptors.

The Cousa objective: a long working distance air objective for multiphoton imaging in vivo

The paper introduces a long working distance air objective for multiphoton imaging in vivo, demonstrating its performance across multiple species and imaging systems.

High fidelity sensory-evoked responses in neocortex after intravenous injection of genetically encoded calcium sensors

The paper demonstrates that intravenous injection of AAV-PhP.eB enables long-term two-photon calcium imaging in the neocortex with high fidelity sensory-evoked responses.

The development of bi-directionally coupled self-organizing neurovascular networks captures orientation-selective neural and hemodynamic cortical responses

This paper models neurovascular networks to show that vascular feedback influences neural map organization and hemodynamic responses.

3-D optogenetic control of arteriole diameter in vivo

This paper develops an optogenetic method to control arteriole diameter in 3D with high spatiotemporal resolution, enabling study of vascular dynamics and blood flow regulation.

Three-photon imaging of synthetic dyes in deep layers of the neocortex

The paper demonstrates three-photon imaging of synthetic calcium dyes in deep neocortical layers of mice to study visual responses.

In Vivo Two-Photon Imaging of Neuronal and Vascular Responses in Mice Chronically Exposed to Ethanol

This study uses in vivo two-photon imaging to show chronic ethanol exposure alters sensory-evoked neuronal and vascular responses in mice, with region-specific neurovascular coupling changes.

The influence of cortical depth on neuronal responses in mouse visual cortex

This study shows that neuronal responsiveness in mouse visual cortex increases with cortical depth, matching levels seen in other species, and suggests differences in V1 function between rodents and mammals.