Philip J. O’Herron

Dual inhibition of sEH and COX-2 Improved Cognition in Alzheimer's Disease via Enhanced Myogenic Response and Cerebral Artery Distensibility

This study shows that dual inhibition of sEH and COX-2 with PTUPB improves cognition in AD rats by enhancing myogenic response and cerebral artery distensibility.

Inhibition of Soluble Epoxide Hydrolase Ameliorates Cerebral Blood Flow Autoregulation and Cognition in Alzheimer's Disease and Diabetes-Related Dementia Rat Models

This study shows that inhibiting soluble epoxide hydrolase (sEH) with TPPU improves cerebral blood flow autoregulation and cognition in Alzheimer's and diabetes-related dementia rat models.

Cortical Acetylcholine Response to Deep Brain Stimulation of the Basal Forebrain

This study examines how different DBS parameters affect cortical acetylcholine levels and shows that peak responses are insensitive to frequency but increase with longer stimulation and donepezil treatment.

Blood pressure variability compromises vascular function in middle-aged mice

This study shows that chronic blood pressure variability impairs vascular function and causes cognitive deficits in middle-aged mice.

Neurovascular coupling and briefCO2 interrogate distinct vascular regulations

The paper investigates whether CO2 contributes to neurovascular coupling by analyzing vascular responses to briefCO2 and whisker stimulation in mice.

The development of bi-directionally coupled self-organizing neurovascular networks captures orientation-selective neural and hemodynamic cortical responses

This paper models neurovascular networks to show that vascular feedback influences neural map organization and hemodynamic responses.

3-D optogenetic control of arteriole diameter in vivo

This paper develops an optogenetic method to control arteriole diameter in 3D with high spatiotemporal resolution, enabling study of vascular dynamics and blood flow regulation.

In Vivo Two-Photon Imaging of Neuronal and Vascular Responses in Mice Chronically Exposed to Ethanol

This study uses in vivo two-photon imaging to show chronic ethanol exposure alters sensory-evoked neuronal and vascular responses in mice, with region-specific neurovascular coupling changes.

The influence of cortical depth on neuronal responses in mouse visual cortex

This study shows that neuronal responsiveness in mouse visual cortex increases with cortical depth, matching levels seen in other species, and suggests differences in V1 function between rodents and mammals.