Serena M. Dudek

This study shows that deleting the immune receptor Lag3 in a familial AD mouse model reduces amyloidosis, microgliosis, and behavioral deficits, suggesting Lag3 as a potential therapeutic target for Alzheimer's disease.

This study investigates the distinct roles of perineuronal nets on CA2 pyramidal cells and parvalbumin-expressing cells in hippocampal-dependent memory using conditional knockout mice.

The paper investigates the effects of mineralocorticoid receptor knockout on CA2 neurons, finding they adopt a CA1-like molecular and morphological phenotype.

This study investigates AAV tropism in hippocampal CA2 neurons, finding high expression of AAV-delivered genetic material due to abundant AAVR and glycan receptors.

The paper investigates how CA2 neuronal activity influences social behavior after acute social stress in mice, finding that CA2 inhibition increases social avoidance and reduces submissive defense behaviors.

This study identifies and characterizes the hippocampal CA2 region in prairie voles and Syrian hamsters using molecular markers, showing similarities to mice but differences in perineuronal net staining.

The paper identifies genetic variants in RGS14 that disrupt nuclear shuttling and impair LTP regulation in hippocampal neurons, with variant LR causing nuclear accumulation and loss of function.

This study shows RGS14 restricts synaptic plasticity in hippocampal CA2 by limiting postsynaptic calcium signaling and downstream pathways.

The paper shows that distinct neuronal activity patterns induce different gene expression programs through specific mechanisms.

This study identifies CaM and CaMKII as novel interacting partners of RGS14 in mouse brain, revealing RGS14 as a CaM effector and CaMKII phosphorylation substrate.

This study investigates the role of CA2 pyramidal neurons in hippocampal oscillations and social behavior using DREADDs in mice, finding bidirectional regulation of low gamma oscillations and impaired social approach with inhibition.