Suppression rather than activation of the integrated-stress-response (GCN2-ATF4) pathway extends lifespan in the fly
Miriam S Götz, Dan J. Hayman, Gracie Adams, Fumiaki Obata, Mirre J. P. Simons
This study shows that suppressing the GCN2-ATF4 pathway extends lifespan in flies, while its activation reduces lifespan, revealing a dual role in aging.
Proceedings of the National Academy of Sciences · Apr 28, 2026Peer-reviewedPhysiology