Author

Miriam S Götz

University of SheffieldORCID 0009-0002-7187-2626Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Approach:genetic perturbation / CRISPR· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Dan J. HaymaniD· 1 shared Fumiaki ObataiD· 1 shared Gracie AdamsiD· 1 shared Mirre J. P. SimonsiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperPhysiology

Dan J. HaymanORCID

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1 paper

Recent·Most cited

PhysiologyProceedings of the National Academy of SciencesPeer-reviewedApr 28, 2026

Suppression rather than activation of the integrated-stress-response (GCN2-ATF4) pathway extends lifespan in the fly

Miriam S Götz, Dan J. Hayman, Gracie Adams…·Mirre J. P. Simons

This study shows that suppressing the GCN2-ATF4 pathway extends lifespan in flies, while its activation reduces lifespan, revealing a dual role in aging.

DOI 10.1073/pnas.2518812123

Drosophilalong-read sequencing

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