Christian Freund

This study investigates the role of GGAs in AP-1-dependent trafficking using CRISPR-Cas9 and live-cell imaging, finding GGAs modulate bi-directional trafficking by preventing AP-1 cargo retrieval.

This study identifies DHHC20 interaction partners in T cells, showing it interacts with Gsβ1γ2 and suggests a model for its role in palmitoylation.

The paper develops a kinetic model to explain variation in HLA-DM susceptibility of MHC-II peptides and identifies two mechanisms shaping antigen presentation.

The paper identifies immunodominant CD4+ T cell epitopes for SARS-CoV-2 antigens by integrating antigen processing systems with in silico tools, revealing distinct processing mechanisms for different antigens.

The paper identifies and characterizes two complex structures of the tandem WW domain of h-FBP21 bound to a peptide from SmB/B, revealing different ligand and domain orientations.

The paper identifies MPP2 as a scaffold protein that links GABAA receptors to the postsynaptic density through super-resolution imaging and mass spectrometry.

The paper shows that binding of PDZ3 ligands to PSD-95's third PDZ domain alters its SH3-GK domain conformation, affecting complex formation with interactors like Gnb5.