Short and long TNF-alpha exposure recapitulates canonical astrogliosis events in human induced pluripotent stem cells-derived astrocytes
Pablo Trindade, Erick Correia Loiola, Juciano Gasparotto, Camila Tiefensee Ribeiro, Pablo Leal Cardozo, Sylvie Devalle, José Alexandre Salerno, Isis Moraes Ornelas, Pítia Flores Ledur, Fabiola Mara Ribeiro, Ana Lúcia Marques Ventura, José Cláudio Fonseca Moreira, Daniel Pens Gelain, Lisiane O. Porciúncula, Stevens Kastrup Rehen
This study shows that human iPSC-derived astrocytes exposed to TNF-alpha recapitulate key astrogliosis features over time, including cytokine secretion, morphological changes, and reduced aspartate uptake.
Glia · Jan 31, 2020Peer-reviewedNeuroscience