Induced pluripotent stem cell-derived astrocytes from patients with schizophrenia exhibit an inflammatory phenotype that affects vascularization
Pablo Trindade, Juliana Minardi Nascimento, Bárbara S. Casas, Tomás Monteverde, Juciano Gasparotto, Camila Tiefensee Ribeiro, Sylvie Devalle, Daniela Sauma, José Cláudio Fonseca Moreira, Daniel Pens Gelain, Lisiane O. Porciúncula, Verónica Palma, Daniel Martins‐de‐Souza, Stevens Kastrup Rehen
This study shows that hiPSC-derived astrocytes from schizophrenia patients have an inflammatory phenotype that reduces vascularization through secreted factors like IL-8.
Molecular Psychiatry · Oct 24, 2022Peer-reviewedNeuroscience