Andrew J. Smith

The paper identifies dynamic mitochondrial phosphoisoforms through genetic perturbations and shows their functional impact on catalysis, import, and cristae architecture.

The paper investigates mitochondrial proteome homeostasis through multiomic analyses of gene perturbations, revealing post-transcriptional regulation and new protein functions.

The paper introduces a method using the Orbitrap Astral mass spectrometer with DIA to rapidly analyze phosphoproteomes, detecting over 80,000 phosphorylation sites in mice.

This study shows that HK2 is not needed for photoreceptor development but is essential for their survival during aging and stress, with its non-enzymatic role in AKT signaling being critical.

This study shows that activating PKM2 with ML-265 protects photoreceptors from stress-induced apoptosis in vitro and in vivo.