Author

Thomas J. Wubben

University of MichiganORCID 0000-0002-5183-3817Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Eric Weh· 4 shared Heather M. Hager· 4 shared Cagri G. BesirliiD· 3 shared Costas Andreas LyssiotisiD· 3 shared Peter SajjakulnukitiD· 3 shared Andrew J. H. SmithiD· 2 shared Katherine M. WehiD· 2 shared Mercy D. Pawar· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersNeuroscience

Eric Weh

Mutual co-authors in cluster

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4 papers

Recent·Most cited

NeuroscienceRedox BiologyPeer-reviewedJun 18, 2026

Redox imbalance dictates dependence on GOT1 versus GOT2 for rod photoreceptor health during aging and stress

Meini Chen, Eric Weh, Moloy T. Goswami…·Thomas J. Wubben

This study shows that GOT1 and GOT2 have opposing roles in rod photoreceptor health, with GOT2 acting as a neuroprotective factor under reductive stress conditions.

DOI 10.1016/j.redox.2026.104266

mouseexperimental assay

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Cell BiologyeLifePeer-reviewedAug 28, 2024

Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival

Moloy T. Goswami, Eric Weh, Shubha Subramanya…·Thomas J. Wubben

16 citationstop 3%

mousemetabolomics

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NeuroscienceCell Death and DiseasePeer-reviewedJun 4, 2020

Hexokinase 2 is dispensable for photoreceptor development but is required for survival during aging and outer retinal stress

Eric Weh, Zuzanna Lutrzykowska, Andrew J. H. Smith…·Cagri G. Besirli

This study shows that HK2 is not needed for photoreceptor development but is essential for their survival during aging and stress, with its non-enzymatic role in AKT signaling being critical.

61 citations

mousebulk RNA-seq

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Molecular BiologyScientific ReportsPeer-reviewedFeb 19, 2020

Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, provides photoreceptor neuroprotection

Thomas J. Wubben, Mercy D. Pawar, Eric Weh…·Cagri G. Besirli

This study shows that activating PKM2 with ML-265 protects photoreceptors from stress-induced apoptosis in vitro and in vivo.

42 citations

ratexperimental assay

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