Cell BiologyeLifePeer-reviewed
Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival
Moloy T. Goswami, Eric Weh, Shubha Subramanya…·Thomas J. Wubben
16 citationstop 3%
Author
Cagri G. Besirli
University of MichiganORCID 0000-0001-7154-2024Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2020-2024 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 39 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship3 papers
Recent·Most cited
- NeuroscienceCell Death and DiseasePeer-reviewed
Hexokinase 2 is dispensable for photoreceptor development but is required for survival during aging and outer retinal stress
Eric Weh, Zuzanna Lutrzykowska, Andrew J. H. Smith…·Cagri G. Besirli
This study shows that HK2 is not needed for photoreceptor development but is essential for their survival during aging and stress, with its non-enzymatic role in AKT signaling being critical.
61 citations - Molecular BiologyScientific ReportsPeer-reviewed
Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, provides photoreceptor neuroprotection
Thomas J. Wubben, Mercy D. Pawar, Eric Weh…·Cagri G. Besirli
This study shows that activating PKM2 with ML-265 protects photoreceptors from stress-induced apoptosis in vitro and in vivo.
42 citations